Jejunum and Ileum

Absorption


Small Intestine

The 3 parts of the Small Intestine:

  1. Duodenum - 30cm

  2. Jejunum - 250cm

  3. Ileum - 300cm

Total Length 580cm - but the shorter you are the shorter your small intestine, likewise the taller the longer. We can happily round it to 6 meters, and this will be the actual length for many people

According to my mathematics, the duodenum accounts for 5% of the length of the small intestine

So the Jejunum + Ileum is 95% - so almost all of the small intestine

We won't look at the jejunum and ileum separately, we will just consider them as 'the small intestine' from here.

The duodenum also does absorption. The duodenum has villi and microvilli and brush-boarder enzymes. The duodenum has capillaries and lacteals inside its villi. But, there was so much happening there, that I thought we'd leave it for this bit.

The small intestine is called small because the pipe is narrow. I would have called it the long intestine. The pipe has a width of about 1.5 - 2cm. About the same width as your finger

The small intestine has a very liquidly mucus to keep the chyme moving along and to protect the small intestine

The chyme is moved along by peristaltic waves aka peristaltic contractions aka peristalsis

Like the esophagus, this peristalsis is a relaxation at the front (by longitudinal muscles) and a squeeze at the back (by circular muscles)

Villi

Villi are finger like projections that increase the surface area of the 6 meter long small intestine.

This increased surface area increases the area for the nutrients to be absorbed

It is hard to calculate the exact surface area of the small intestine. Depending on the source calculations, the surface area ranges from one side of a badminton court, to an entire tennis court. The point being that the surface area is very large.

The chyme that passes through the small intestine has a consistency much like 'cup-a-soup'. So by increasing the surface area, even if it is just half a badminton court. then it is like blending and pureeing your dinner until it is drinkable, and then using a paint brush and having to coat the entire half badminton court, every corner of it, with your pureed dinner

In the clip called normal small bowel (American for Small Intestine) you can see all the villi

Microvilli

If we zoom in to a single Villi we will find that it has a fuzzy looking outside.

We keep zooming in we see that the fuzziness continues

It is so fuzzy that you can only see what is causing the fuzziness by zooming in with an electron microscope

It is so fuzzy, that it kind of resembles the bristles on a brush.

Because of this, the lining is also called the 'brush-border'

The bristles on this brush border are called microvilli

These microvilli massively increase the surface area of the small intestine

It is here, at the microvilli, that the nutrients are absorbed

The Microvilli do the job of absorbing the nutrients. The fat, protein and carbohydrates. And where these nutrients go, water follows.

In this microscopic area right next to the villi are the last few digestive enzymes. We don't need to know about them, but it is nice to.

So, these are:

Intestinal Carboxylases - sucrase and maltase. These cut the disaccharides that amylase has created into just single units or monosaccharides. These monosaccharides are glucose, fructose.

The glucose is then absorbed by the micro-villi into the cell. The glucose then moves from the cell into the villi and into the blood stream.

Because of this, the disaccharides right next to the villi 'disappear'. So, more disaccharides move into that space next to the villi due to diffusion (moving from an area of high concentration in the lumen of the intestine, to an area of low concentration in the brush boarder).

But then, these disaccharides are digested and 'disappear'. They disappear because glucose is not a disaccharide. Glucose could indeed diffuse away, back into the lumen, but it is taken into the cells too quickly for this to happen


The same process happens with Protein. Some of the tripeptides and dipeptides (three or two amino acids) are cut up by Intestinal Proteases and become just amino acids, thus changing the concentration gradient and causing diffusion of the tripeptides and dipeptides over to the brush boarder. Also, the cells of the villi can absorb tripeptides and dipeptides without them needing to be single amino acids, so this also causes them to disappear

Of course, the same happens with fat. With the monoglyceride being cut by Intestinal Lipase into glycerol and a fatty acid

Intestinal digestive enzymes cut the small already digested nutrients into their smallest part, to:

  1. Assist in the movement of the nutrients from the lumen through the cells and into the blood vessels and lacteals of the villi

  2. Maintain a diffusion gradient that causes nutrients that are in the lumen to diffuse to the villi

Lacteals and Fatty Lymph

When looking at drawings of the villi we can see a green pipe. Naturally, the pipe is not actually green, it just in the drawings to make the pipe stand out. But what is this pipe? What does it do and where does it go?

The green pipe does not contain any red blood cells - the liquid in it is mostly water.

When you cut yourself, you see your red blood. Blood is red because it contains cells that are red. A scab starts to form, this is a mesh-work that captures the red blood cells before they can leave. Once a scab has formed you can pick it, sometimes a liquid will come out - this is plasma. The scab and the repairing of the blood vessels is stopping the red blood cells form leaving, however the liquid that the blood vessels float in can still leak past. This liquid is plasma. Plasma is mostly water.

This leaking for things smaller than red blood cells, out of the blood vessels, happens everywhere. This is how nutrients get to the cells - they leak out of the blood and diffuse towards cells.

Water leaks out of the blood vessels. This is why if you stand all day as a Queens guard or some other job that requires you to stand in a spot and not move for hours, your lower legs and feet will swell.

So, how does the water get back into the blood?

The water will move from the blood vessels into the tissue, and then into these pipes. These pipes are called Lymphatic Vessels. Here there is water, and some immune cells - some white blood cells. In fact the white blood cells hang out in big 'rooms' that are part of this piping system, called Lymph nodes. They are here because if their is an infection in some part of the body, like your toes, then some of the 'help' signals sent out by the tissues in the toe will travel up the lymph and can be detected by the white blood cells hanging out in the lymph nodes and they will ramp up the immune response. Sometimes, some of the bacteria will also try to sneak up these lymphatic vessels - then there is a huge response and you might even get swollen lymph nodes.

Why is the Lymphatic system in the small intestine?

Well, firstly it is everywhere. Where ever there are blood vessels there are lymphatic vessels.

Secondly, it has a job to do there

Into each villus is a vine of the lymphatic vessels called a Lacteal

Fat moves through the villus into the lacteal.

The fluid in the lymphatic vessels draining the small intestine looks different from the fluid in the rest of the lymphatic system.

In most of the lymphatic system it is a nearly transparent, slightly white liquid. However, coming back form the Small Intestine, it looks more like watery milk due to all the fat that it contains. This liquid is called Chyle.

The lymphatic system takes the fat up to near the heart. Emptying into a Vein near the left collar-bone (Left Subclavian Vein).

Once in the blood, or the cardiovascular system, the fat will travel to the heart, then to the lungs (so the blood can pick up some oxygen) then to the rest of the body where it will be stored or burnt

The clip below has a brilliant explanation and animation of the function of Lacteals as well as the Capillaries in the Villi and the mesnteric vasculature - it is overall fantastic - watch it :-)

Capillaries


How the

THe Mesenteric ArterieS

Connects to the

the Hepatic Portal Vein

Arteries take blood Away from the heart

Veins return, or 'veturn' (say it like Count Dracula) the blood to the heart

Arteries are like the top of a tree, splitting into smaller and smaller branches and twigs.

Veins are like the roots of a tree, starting off tiny, then joining into larger and larger roots

But in this weird tree, the roots touch the twigs. This junction is called the Capillaries

Capillaries are absolutely everywhere in the human body

Capillaries are where the gases move and the nutrients move

Capillaries are tiny, they are slightly narrower than a red blood cell is wide, causing the red blood cells to change from a donut shape into more of a parachute shape (this is actually the reason for their donut shape, as they become a parachute their diameter reduces)

The vessels of the Cardiovascular system are ordered for two things

  1. Transport

  2. Exchange

The size of the vessel indicates what is happening there

The biggest vessels are Arteries and Veins. These are for transport - very little exchange happens here.

The next are Arterioles (little arteries) and Venules (little veins) these are also for transport with a focus on distribution

Finally the Capillaries - these connect the Arterioles that are taking blood away from the heart, with the venules that are returning blood to the heart. This is where Exchange happens

The exchange is happening between the blood and the cells of the tissues

This exchange is of nutrients, oxygen, carbon dioxide and waste.

Often you'll hear blood vessels and roads being compared.

This is why you'll often here the phrases 'the major artery away from the city' and all of the 'arterial routes' out of the city.

An analogy would be buying a 'My Food Bag"

Arteries and Veins = Motorways away and returning to the CBD where the My food bag HQ is

Arterioles and Venioles = main streets

Capillaries = narrow one way side streets

Exchange = The Courier guy slowing down his van, but not stopping, and throwing your Food bag out his window at your house, while at the same time you pick up rubbish and throw it at him, getting it through the open van window

Villi Capillaries

Uber for Sugar and the bits of proteins

Watch this clip, it is really good!!

The small intestine is supplied with oxygen rich blood from the Mesenteric Arteries. These branch becoming smaller and smaller until finally you have blood vessels that are so small they can only fit one blood cell at a time. These are the Capillaries

Here gas exchange and nutrient exchange occurs

The Oxygen in the leaves the capillaries and moves into the cells of the villi to keep them alive. Carbon Dioxide moves from the cells of the villi into the capillary to the be moved ultimately to the lungs

The nutrients move into the blood vessels. But only the water soluble ones; sugars and bits of proteins!

Capillaries in the Villi take up the Sugars and Amino acids (and peptides) that are absorbed through the wall of the villus

Villi = plural, lots of little fingers

Villus = singular, one finger

The Capillaries then take these nutrients to the liver for processing before returning to the heart.

To get to the Liver the capillaries join into veins that get bigger and bigger as more and more veins join together until they finally get to the highway, the big main vein going from the intestines to the liver, the Hepatic Portal Vein

So it goes:

Arteries - Arterioles (the little artery branches) - capillaries - venioles (little vein branches) - veins

With the digestive system, it goes:

Mesenteric arteries - arterioles - capillaries - venioles - veins

These veins then collect in the Hepatic Portal Vein

Hepatic means liver

The Hepatic Portal Vein takes all the blood from the intestines to the liver for processing

Coeliac disease

Aka Celiac disease Aka Celiacs aka Coeliacs

Inflammation is a major cause of disability and death.

The immune system can damage healthy tissue as collateral damage when it is at war with something.

The immune system can be looked at like the USA Military - especially their 'strategic missile strikes' - highly effective at removing enemies. However, also takes out allies.

This happens with Cardiovascular disease

This also happens with Coeliac

The persons immune system is targeting an enemy

Unfortunately the enemy looks like gluten

So, the immune system targets gluten which is made in Wheat

Unfortunately for suffers. Most of our Flour, and thus almost all products made with flour (cakes, bread, muffins, pasta) contain gluten.

They can switch to gluten free meal for their starch - like potatoes and rice.

However flour products are everywhere, imaging not being able to eat any bread?

They don't know that they have Coeliac disease until it has progressed to the point where they have symptoms:

  1. Sore tummy after they have eaten flour products - due to inflammation in the intestines

  2. Watery feces - due to the inflammation

  3. Weight loss and low iron - why would this be?

Overtime the inflammation damages the villi

The villi get smaller. Getting smaller is called 'atrophy'

Because the villi are smaller there is less surface area for absorption of nutrients.

Thus, less nutrients are absorbed

The suffers run the risk of lacking certain vital nutrients.

These include vitamins and minerals such as Iron and Calcium

The chronic inflammation in the small intestine can cause extreme damage including ulceration so it needs to be checked and treated

Have a look at the comparison clip below. This shows an Endoscope moving through the small intestine of a person without celiacs on one side and on the other side, the intestine of a person with ceoliac disease.

What did you notice in the clip above?

Try to look at the villi

Is one intestine looking smoother than the other? Why would that be?

Have a play with a digestive system

Watch these 2 clips - they cover everything

The clip below has a brilliant explanation and animation of the function of Lacteals as well as the Capillaries in the Villi and the mesnteric vasculature - it is overall fantastic - also it only lasts for 3.5 minutes :-)

This one is also extremely good. It covers the entire digestive process. It takes about 14 minutes

If you haven't watched it yet, now is the time :-)